How to use

How to order

Hydrozid® PRECISE is applied according to illustration A, B, and C below

Step A

Remove Hydrozid® PRECISE from the pack. Hydrozid® PRECISE is locked (the disc extension is placed to the left). This feature prevents unintended spraying both while carrying Hydrozid® PRECISE or between treatments.

Step B

Move the disc extension to the right to open the spray head. Hydrozid® PRECISE is applied to a lesion directly from the canister via the spray head. Do NOT attempt to remove the tip mounted on to the spray head.

Step C

Hydrozid® PRECISE is now ready to use.

Use one of the application templates provided to protect the surrounding tissue, select the hole matching the size of the individual lesion. Ensure to place and hold the application template as close as possible to the patient’s skin/mucosa, in order to reduce the risk of the cryogen flowing beneath the application template and hitting healthy tissue.

Push the trigger gently and freeze the lesion from a distance of approximately 1 cm. Applying from less than 1 cm from the lesion, may affect the treatment outcome and increase the risk of the cryogen splattering or flowing and hitting the surrounding healthy tissue.

Each freeze should be followed by a complete and natural thaw, the thaw is complete when the ice ball on the lesion disappears, which may take up to 30 seconds. Premature warming of the cells will minimize the effectiveness of the freeze, and the procedure may need to be repeated.

Repeat the freeze thaw cycle if needed.

The freeze time and freeze-thaw cycles may vary according to the type of lesion being treated, the size of the lesion as well as the anatomical location and the recommendations can range from 3-6 seconds of freeze for 2 to 6 applications (see the recommendations in the treatment table below).

The healthcare professional should always assess the individual patient and lesion to determine the correct treatment.

As hypopigmentation and scarring is more frequently associated with single, long spray times, care should be taken when determining how long to freeze.

Some lesions may need repeated treatment to be completely removed. When repeated treatment is needed, intervals of 1 to 2 weeks between treatments are typically recommended. However, the treatment intensity and the number of treatments depend on the individual patient and their clinical response. This is to be assessed by the healthcare professional.

Complete healing takes about 10 to 14 days but is individual.

Recommended treatment times

The freeze times provided in the table below are only recommendations. The recommendations are per lesion per treatment session. The healthcare professionals should always assess the individual patient and lesion to determine the correct treatment.

Lesion Recommended freezing times

Allow a complete thaw before freezing again

Recommended number of repetitions
Verruca plantaris (plantar warts) 6 seconds 4 to 6 times
Verruca vulgaris (common warts) 6 seconds 4 to 6 times
Verruca plana (flat warts) 3 seconds 6 times
Seborrheic keratosis 6 seconds 2 to 3 times
Lentigo (age spots) 3 seconds 2 times
Acrochordon (skin tags) 3 to 6 seconds 2 times
Actinic keratosis  4 to 5 seconds 2 times
Molluscum contagiosum 3 to 6 seconds 2 times
Condyloma (genital warts) 6 seconds 2 to 6 times
Gingival melanin hyperpigmentation 3 to 6 seconds 2 times
Last updated in: 2023/10/05


Cryosurgery may produce a stinging, painful or burning sensation on the skin/mucosa during and after freezing, which will rapidly fade away after the thawing phase. Swelling and erythema after treatment is common. The treatment may result in the development of a scab or blister in the treated area. Cryosurgery may potentially cause pigmentation changes or hair loss in hair bearing areas. The pigmentation changes usually occur as hypopigmentation, but post-inflammatory hyperpigmentation can also occur.

Post-treatment care: The patient should not scratch or pick in the treated area. The area should be kept clean and protected against sunlight.

Contraindications: Cryosurgery is contraindicated in patients with cryoglobulinemia, Raynaud’s disease (especially when the lesion is on fingers, toes, nose, ears, penis), cold urticaria, blood dyscrasias, or uncertain diagnosis (if there is doubt, a biopsy is recommended to determine classification and if cryosurgery with Hydrozid® PRECISE is an option).

Caution: Improper or imprudent use can produce damage to the dermis and consequent scar formation and nerve damage. Do not spray on healthy skin/mucosa.

Never spray on open wounds, cuts, irritated and delicate or eczematous skin. Special caution is advised if treating patients who have impaired immune system, poor blood supply or diabetes, patients with sensitive or heavily pigmented skin, neuropathy, pyoderma gangrenosum or when treating children or elderly. Those with collagen vascular disease, diabetes, stasis problems, pyoderma gangrenosum, neuropathy, impaired immune system, and ulcerative bowel disorders may present special complications including, but not limited to, slower healing time. The healthcare professional’s discretion should be used for patient and treatment selection.

Disposal: Disposal should be in accordance with local, state, or national legislation. Hydrozid® PRECISE is non-flammable.

Shelf life: Up to 3 years (see canister), under normal storage conditions.

Storage: Room temperature. Store upright, out of direct sunlight, and do not expose to temperatures exceeding 50°C. If you are planning to transport Hydrozid® PRECISE in hot conditions, it is advisable to place the canister in a cooler or an area where temperatures do not exceed 50°C.


  • Hydrozid® PRECISE should be used by healthcare professionals only.
  • Do not attempt treatment without the application templates until you have substantial experience and are familiar with the device and recommended treatment times. It is solely at the healthcare professional’s discretion to decide and to ensure it is safe and suitable to treat without the use of the application templates. Failure to use an application template and attempt an open spray could result in damage to the surrounding or underlying healthy tissue.
  • Never attempt to remove the tip mounted on to the spray head. The narrow aperture of the tip makes it easier to target the lesion mitigating the risk of damaging the surrounding healthy tissue. The tip also comprises a conical inner shape that prevents condensation and dripping during the treatment.
  • May be used on individuals from 5 years of age and up.
  • The application templates provided must only be used with Hydrozid® PRECISE. Due to the risk of cross-contamination/infection, each application template should only be used for one patient (and one type of lesion only), and subsequently be discarded.
  • Avoid contact with Do not inhale. Keep out of reach of children.
  • Read the instructions for use prior to treating with Hydrozid® PRECISE


Web page last updated: 2023/10/30

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How to order